Palmitoyl hexapeptide-12 is the palmitic acid ester of a synthetic peptide consisting of two or more amino acids, it significantly stimulated human skin fibroblast proliferation, mediated through a binding of the peptide to a plasmalemmal receptor of human skin fibroblast, palmitic acid ester promote the penetrativity. Palmitoyl hexapeptide-12 can promote the collagen, elastin and hyaluronic acid on proliferation. It can be used to improve the skin's water content, increase the thickness of the dermis, reduce microgroove. The main effect is to increase the elasticity of skin, and increase skin thickness. In addition, it stimulates cell communication and then repairs the age related skin damage. Therefore, this product can be recommended to use in cosmetic products as anti-aging, wrinkle smoothing and cutaneous barrier repair.